IgM antibody profile in patients with typhoid fever at a general hospital
Keywords:
typhoid fever, immunoglobulin M antibodies, serological diagnosis, immunochromatographic test, clinical laboratoryAbstract
Typhoid fever remains a significant public health problem in endemic areas, so accurate and timely diagnosis is crucial in supporting clinical management. Serological testing for immunoglobulin M antibodies has been widely used to support early diagnosis, especially in health care facilities with limited laboratory resources. This study aimed to describe the immunoglobulin M antibody profile in patients with a clinical diagnosis of typhoid fever who underwent serological testing at a general hospital. This study used a descriptive observational design with a cross-sectional approach. Venous blood samples were taken from 20 patients suspected of having typhoid fever and analyzed using an immunochromatography test. Data analysis was performed descriptively. The results showed that most patients had positive immunoglobulin M test results. It indicates the presence of acute or ongoing infection. Meanwhile, the rest showed negative results, likely because testing was performed early in the infection before optimal antibody levels. These findings confirm the role of immunoglobulin M testing as a relevant diagnostic tool in detecting acute typhoid fever. Interpretation of serology results needs to consider the clinical context and timing of sample collection in order to make clinical decisions more accurate in healthcare practice.
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